Cholesterol Depletion from the Plasma Membrane Impairs Proton and Glutamate Storage in Synaptic Vesicles of Nerve Terminals

Abstract

We report that cholesterol depletion with methyl-β-cyclodextrin (MβCD) acutely applied to rat brain synaptosomes is accompanied by an immediate increase in transporter-mediated glutamate release and decrease in exocytotic release. To clarify the possible mechanisms underlying these phenomena, we investigated the influence of MβCD on synaptic vesicle… (More)
DOI: 10.1007/s12031-010-9351-z

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@article{Tarasenko2010CholesterolDF, title={Cholesterol Depletion from the Plasma Membrane Impairs Proton and Glutamate Storage in Synaptic Vesicles of Nerve Terminals}, author={Alla S. Tarasenko and Roman V. Sivko and Natalia V. Krisanova and Nina H. Himmelreich and Tatiana A. Borisova}, journal={Journal of Molecular Neuroscience}, year={2010}, volume={41}, pages={358-367} }