Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.

@article{Jones1993Cholesterol7A,
  title={Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.},
  author={Minh P. Jones and William M. Pandak and Douglas M. Heuman and John Y. L. Chiang and Phillip B. Hylemon and Z Rano Vlahcevic},
  journal={Journal of lipid research},
  year={1993},
  volume={34 6},
  pages={885-92}
}
Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation. The role of cholesterol in the regulation of cholesterol 7 alpha-hydroxylase and the interrelationship between the cholesterol and bile acid biosynthesis pathways remain controversial. The objective of the present study was to define the role of cholesterol in the regulation of… CONTINUE READING

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