Cholesterol‐Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway

  title={Cholesterol‐Sensitive Cdc42 Activation Regulates Actin Polymerization for Endocytosis via the GEEC Pathway},
  author={Rahul Chadda and M. Howes and S. Plowman and J. Hancock and R. Parton and S. Mayor},
  • Rahul Chadda, M. Howes, +3 authors S. Mayor
  • Published 2007
  • Biology, Medicine
  • Traffic
  • Glycosyl‐phosphatidylinositol (GPI)‐anchored proteins (GPI‐APs) are present at the surface of living cells in cholesterol dependent nanoscale clusters. These clusters appear to act as sorting signals for the selective endocytosis of GPI‐APs via a Cdc42‐regulated, dynamin and clathrin‐independent pinocytic pathway called the GPI‐AP‐enriched early endosomal compartments (GEECs) pathway. Here we show that endocytosis via the GEECs pathway is inhibited by mild depletion of cholesterol, perturbation… CONTINUE READING
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