Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts

@article{Kromhout1995CholesterolDB,
  title={Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts},
  author={Daan Kromhout},
  journal={The Lancet},
  year={1995},
  volume={346},
  pages={1647-1653}
}
  • D. Kromhout
  • Published 30 December 1995
  • Medicine
  • The Lancet
The associations of diastolic blood pressure with the risk of stroke in Western and Eastern populations.
TLDR
Evidence from two overviews of prospective, observational studies of the association of diastolic blood pressure (DBP) with the risk of stroke in populations from the US and Europe and populations from China and Japan suggests that the potential benefits of blood pressure lowering may be greater in Eastern Asia.
HDL-Cholesterol, total cholesterol, and the risk of stroke in middle-aged British men.
TLDR
Higher levels of HDL cholesterol were associated with a significant decrease in risk of stroke even after adjustment for potential confounders and the marked inverse association between HDL cholesterol and stroke seen in hypertensives emphasizes the importance of those modifiable risk factors for stroke known to lower the concentrations of HDLolesterol.
Age-related changes in stroke risk in men with hypertension and normal blood pressure.
TLDR
It appears that other unidentified factors have an increasing role in the causation of stroke with advancing age, and the value of aggressive screening and treatment of hypertension in this age group is not negated.
Blood Pressure and Stroke: An Overview of Published Reviews
TLDR
The epidemiologically expected benefits of BP lowering for stroke risk reduction are broadly consistent across a range of different population subgroups and initiating and maintaining BP reduction for stroke prevention is a more important issue than choice of initial agent.
Blood pressure and stroke: an overview of published reviews.
TLDR
The epidemiologically expected benefits of BP lowering for stroke risk reduction are broadly consistent across a range of different population subgroups, and there are greater benefits from larger BP reductions.
Cholesterol Predicts Stroke Mortality in the Women’s Pooling Project
TLDR
The results show that cholesterol is a risk factor for nonhemorrhagic stroke death in women <55 years of age and is more strongly associated with mortality in black women < 55 years ofAge than in white women.
Higher Total Serum Cholesterol Levels Are Associated With Less Severe Strokes and Lower All-Cause Mortality: Ten-Year Follow-Up of Ischemic Strokes in the Copenhagen Stroke Study
TLDR
The hypothesis that a higher cholesterol level favors development of minor strokes is supported, as major strokes are more often seen in patients with lower cholesterol levels, and poststroke mortality is inversely related to cholesterol.
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Reduction of blood pressure, cessation of smoking, lowered cholesterol, and increased physical activity at leisure are individual measures to reduce the risk of stroke.
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Blood cholesterol concentration was directly related to mortality from coronary heart disease even in those with what was, by Western standards, a "low" cholesterol concentration.
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There was a significant inverse association between serum cholesterol and the risk of intracerebral hemorrhage but not of subarachnoid hemorrhage, and the inverse association was stronger for normotensive than for hypertensive men.
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