Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

@article{Yip2001CholesterolAM,
  title={Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.},
  author={Christopher M Yip and E A Elton and Audrey A Darabie and Marcelle R. Morrison and JoAnne McLaurin},
  journal={Journal of molecular biology},
  year={2001},
  volume={311 4},
  pages={723-34}
}
Recent studies have suggested that cholesterol, an important determinant of the physical state of biological membranes, plays a significant role in the development of Alzheimer's disease. We have employed in situ scanning probe microscopy, fluorescence anisotropy, and electron microscopy to investigate how cholesterol levels within total brain lipid bilayers effect amyloid beta-peptide (Abeta)-assembly. Fluorescence anisotropy measurements revealed that the relative fluidity of the total brain… CONTINUE READING