Cholesterol, LDL, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bEnd.3).

@article{Ning2006CholesterolLA,
  title={Cholesterol, LDL, and 25-hydroxycholesterol regulate expression of the steroidogenic acute regulatory protein in microvascular endothelial cell line (bEnd.3).},
  author={Yanxia Ning and Sifeng Chen and Xiaobo Li and Yongjie Ma and Fengdi Zhao and Lianhua Yin},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 4},
  pages={1249-56}
}
The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system. In this experiment, we first demonstrated that StAR expressed in endothelial cells as well. Immunochemistry showed positive staining of StAR in endothelial cells. To investigate whether steroids and oxysterols regulate StAR expression in endothelial cells, mouse brain microvascular endothelial cell line (bEnd.3) was treated with various steroids… CONTINUE READING