Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.

@article{Song2000CholestenoicAI,
  title={Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.},
  author={Ching Song and Shutsung Liao},
  journal={Endocrinology},
  year={2000},
  volume={141 11},
  pages={4180-4}
}
Excessive cholesterol is eliminated from extrahepatic cells by reverse cholesterol transport, a process by which neutral sterols are transferred to extracellular acceptor lipoproteins for further transport to the liver. Another process independent of lipoproteins involves excretion of 3beta-hydroxy-5-cholesten-25(R)-26-carboxylic (cholestenoic) acid, a metabolite of 27-hydroxycholesterol. Physiological concentrations of cholestenoic acid activated the nuclear receptor liver X receptor alpha… CONTINUE READING

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