Cholestatic steroid hormones inhibit taurocholate uptake into isolated rat hepatocytes.

@article{Schwarz1977CholestaticSH,
  title={Cholestatic steroid hormones inhibit taurocholate uptake into isolated rat hepatocytes.},
  author={Leslie R. Schwarz and Michael Schwenk and Erich Pfaff and Helmut A. Greim},
  journal={Biochemical pharmacology},
  year={1977},
  volume={26 24},
  pages={
          2433-7
        }
}
  • Leslie R. Schwarz, Michael Schwenk, +1 author Helmut A. Greim
  • Published 1977
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Abstract The effect of three cholestatic steroids (norethandrolone, 17-β-estradiol and progesterone) on hepatocellular uptake and secretion of taurocholate was studied in isolated rat liver cells. The steroids decreased the rate of taurocholate uptake. Norethandrolone inhibited uptake noncompetitively with a K i of 18 μM, but had no effect on the activation energy of uptake. 17-β-estradiol and progesterone reduced taurocholate uptake by 50 per cent at concentrations between 40 μM and 50 μM. The… CONTINUE READING

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