Cholestatic bile acids inhibit gap junction permeability in rat hepatocyte couplets and normal rat cholangiocytes.

@article{Boucherie2005CholestaticBA,
  title={Cholestatic bile acids inhibit gap junction permeability in rat hepatocyte couplets and normal rat cholangiocytes.},
  author={Sylviane Boucherie and Om{\'e}dine Koukoui and Val{\'e}rie Nicolas and Laurent Combettes},
  journal={Journal of hepatology},
  year={2005},
  volume={42 2},
  pages={244-51}
}
BACKGROUND/AIMS The aim of this work was to study the effects of different bile acids on the permeability of gap junction channels (PGJC). We also looked at the effects of some bile acids on the coordination of intercellular calcium oscillations. METHODS The permeability of gap junctions was assessed by fluorescent dye transfer and calcium signalling on fluorescent microscopy. RESULTS Cholestatic bile acids such as taurolithocholate, taurolithocholate-sulfate and taurochenodeoxycholate… CONTINUE READING