Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.

@article{Bhme1994CholestasisCB,
  title={Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver.},
  author={Matthias B{\"o}hme and Michael M{\"u}ller and Inka Leier and Gabriele Jedlitschky and Dietrich Keppler},
  journal={Gastroenterology},
  year={1994},
  volume={107 1},
  pages={255-65}
}
BACKGROUND/AIMS Inhibition of bile salt transport across the hepatocyte during cholestasis induced by cyclosporin A has been shown. However, the contribution of the different bile salt transport systems in liver to cholestasis has remained controversial. METHODS The sensitivity of different bile salt transport systems in liver to cyclosporin-induced inhibition was determined by transport assays in plasma membrane vesicles and by in vivo studies in the rat. RESULTS Cyclosporin A--induced… CONTINUE READING

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