Cholestasis and the role of basolateral efflux pumps.

@article{Keppler2011CholestasisAT,
  title={Cholestasis and the role of basolateral efflux pumps.},
  author={Deana Keppler},
  journal={Zeitschrift fur Gastroenterologie},
  year={2011},
  volume={49 12},
  pages={
          1553-7
        }
}
ATP-dependent transport of biliary constituents, such as bile acids, reduced glutathione, and bilirubin glucuronosides across the hepatocyte canalicular membrane into bile represents the decisive driving force for the formation of biliary fluid. Functional characterization, cloning, and localization of hepatocellular transporter proteins has provided a molecular understanding of the mechanisms underlying bile flow and intrahepatic cholestasis. Genetic variants in humans and genetic knockout in… CONTINUE READING
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