Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.

@article{Bromander1991CholeraTS,
  title={Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.},
  author={Annakari Bromander and Jan Holmgren and Nils Y Lycke},
  journal={Journal of immunology},
  year={1991},
  volume={146 9},
  pages={2908-14}
}
Cholera toxin (CT) is a strong systemic and mucosal adjuvant that greatly enhances IgG and IgA immune responses. We investigated whether CT potentiates Ag presentation by macrophages as a possible mechanism underlying its adjuvant function. This was tested by preculturing APC in CT and analyzing the effect of CT treatment on the capacity to trigger 1) an allogeneic proliferative response of normal mesenteric lymph node T cells (H-2b) to the macrophage cell line P388D1 (H-2d) or 2) an Ag… CONTINUE READING
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Showing 1-10 of 24 references

Cholera toxin acts isotype differentiation

  • W. Ealding
  • J . Immunol .
  • 1990

Detection of ILla response

  • S. B. Mizel
  • J . Immunol .
  • 1990

Cholera toxin promotes B cell lmrnunol

  • E. Severinson, W. Strober
  • 1989

Evidence aldehyde - treated murine macrophages

  • P. W.. D. Glaister. E. Chen Gray
  • Eur . J . Immunol .
  • 1989

Immunol . 143 : 2514

  • H.. C. Ghunter Streck, H. U. Beuscher, M. Rollinghoff
  • 1989

Lipopoly - saccharide - induced gene expression in murine peritoneal macrophages i selectively suppressed by agents that elevate intracellular CAMP

  • G. Pattison lmboden. J. B.. D. M. Shobak
  • 1989

The effect of gamma interferon human monocytes

  • S. Davies, D. W. Scott
  • J . lmmunol .
  • 1989

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