Cholera toxin perturbs the paracellular barrier in the small intestinal epithelium of rats by affecting claudin-2 and tricellulin

@article{Markov2019CholeraTP,
  title={Cholera toxin perturbs the paracellular barrier in the small intestinal epithelium of rats by affecting claudin-2 and tricellulin},
  author={A. Markov and O. Vishnevskaya and L. S. Okorokova and A. A. Fedorova and N. M. Kruglova and O. V. Rybalchenko and J. Aschenbach and S. Amasheh},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2019},
  pages={1-7}
}
  • A. Markov, O. Vishnevskaya, +5 authors S. Amasheh
  • Published 2019
  • Chemistry, Medicine
  • Pflügers Archiv - European Journal of Physiology
  • Cholera toxin is commonly known to induce chloride secretion of the intestine. In recent years, effects on epithelial barrier function have been reported, indicating synergistic co-regulation of transporters and tight junction proteins. Our current study focused on the analysis of cholera toxin effects on transepithelial resistance and on tight junction proteins, the latter known as structural correlates of barrier function. Ligated segments of the rat jejunum were injected with buffered… CONTINUE READING
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