Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.

@article{SnchezBlzquez1991CholeraTA,
  title={Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.},
  author={Pilar S{\'a}nchez-Bl{\'a}zquez and J. Rodŕıguez Garz{\'o}n},
  journal={Life sciences},
  year={1991},
  volume={48 18},
  pages={
          1721-7
        }
}
Cholera toxin, an agent that impairs the function of Gs transducer proteins, was injected (0.5 microgram/mouse, icv) and the antinociceptive activity of opioids and clonidine was studied 24h later in the tail-flick test. In these animals, an enhancement of the analgesic potency of morphine, beta-endorphin and clonidine could be observed. Cholera toxin did not modify the antinociception evoked by the enkephalin derivatives DAGO and DADLE. Pertussis toxin that catalyses the ADP ribosylation of… CONTINUE READING

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