Cholera toxin and cell growth: role of membrane gangliosides.

@article{Hollenberg1974CholeraTA,
  title={Cholera toxin and cell growth: role of membrane gangliosides.},
  author={Morley D Hollenberg and Peter Fishman and Vann Bennett and Pedro Cuatrecasas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1974},
  volume={71 10},
  pages={4224-8}
}
The binding of cholera toxin to three transformed mouse cell lines derived from the same parent strain, and the effects of the toxin on DNA synthesis and adenylate cyclase activity, vary in parallel with the ganglioside composition of the cells. TAL/N cells of early passage, which contain large quantities of gangliosides G(M3), G(M2), G(M1), and G(Dla), as well as the glycosyltransferases necessary for the synthesis of these gangliosides, bind the most cholera toxin and are the most sensitive… CONTINUE READING

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