Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.

@article{OlveraGomez2012CholeraTA,
  title={Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.},
  author={Irlanda Olvera-Gomez and Sara E. Hamilton and Zhengguo Xiao and Carla Patricia Guimaraes and Hidde L. Ploegh and Kristin A Hogquist and Liangchun Wang and Stephen C Jameson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 6},
  pages={2072-7}
}
The ability to induce humoral and cellular immunity via antigen delivery through the unbroken skin (epicutaneous immunization, EPI) has immediate relevance for vaccine development. However, it is unclear which adjuvants induce protective memory CD8 T-cell responses by this route, and the molecular and cellular requirements for priming through intact skin are not defined. We report that cholera toxin (CT) is superior to other adjuvants in its ability to prime memory CD8 T cells that control… CONTINUE READING

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