Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells.

@article{GeorgeChandy2001CholeraTB,
  title={Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells.},
  author={Annie George-Chandy and Kristina Eriksson and Michael Lebens and Inger Nordstr{\"o}m and E Sch{\"o}n and Jan Holmgren},
  journal={Infection and immunity},
  year={2001},
  volume={69 9},
  pages={5716-25}
}
Cholera toxin B subunit (CTB) is an efficient mucosal carrier molecule for the generation of mucosal antibody responses and/or induction of systemic T-cell tolerance to linked antigens. CTB binds with high affinity to GM1 ganglioside cell surface receptors. In this study, we evaluated how conjugation of a peptide or protein antigen to CTB by chemical coupling or genetic fusion influences the T-cell-activating capacity of different antigen-presenting cell (APC) subsets. Using an in vitro system… CONTINUE READING

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