Corpus ID: 556798

Cholera toxin: A paradigm of a multifunctional protein

  title={Cholera toxin: A paradigm of a multifunctional protein},
  author={Kaushik Bharati and N. Ganguly},
  journal={The Indian Journal of Medical Research},
  pages={179 - 187}
  • Kaushik Bharati, N. Ganguly
  • Published 2011
  • Medicine, Biology
  • The Indian Journal of Medical Research
  • Cholera toxin (CT) was discovered exactly half a century ago by S.N. De. We have come a long way since this epoch-making discovery. Retrospectively, science had to wait a long time since Koch’s prediction of the existence of a toxin, and its actual discovery by De. CT is not just another enterotoxin that causes the signs and symptoms of the dreaded disease, cholera. It is unique in many respects, starting from its structure to its functions. CT is a multifunctional protein that is capable of… CONTINUE READING
    61 Citations
    As a genetic adjuvant, CTA improves the immunogenicity of DNA vaccines in an ADP-ribosyltransferase activity- and IL-6-dependent manner.
    • 11
    • Highly Influenced
    Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection
    • 11
    • PDF
    The Molecular Basis of Toxins’ Interactions with Intracellular Signaling via Discrete Portals
    • 8
    • PDF


    Production of highly purified choleragen and choleragenoid.
    • 199
    Role of the W07-toxin on Vibrio cholerae-induced diarrhoea.
    • 13
    Mutants in the ADP-ribosyltransferase Cleft of Cholera Toxin Lack Diarrheagenicity but Retain Adjuvanticity
    • 231
    • PDF
    A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.
    • 325
    • PDF
    The three-dimensional crystal structure of cholera toxin.
    • 295
    • PDF
    Purification and Characterization of Novel Toxin Produced by Vibrio cholerae O1
    • 15
    • PDF