Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches

@article{Anosova2008CholeraTE,
  title={Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches},
  author={Natalie G. Anosova and Sophie Chabot and Vijay K. Shreedhar and Jason A. Borawski and Bonny L. Dickinson and Marian R. Neutra},
  journal={Mucosal Immunology},
  year={2008},
  volume={1},
  pages={59-67}
}
The follicle-associated epithelium (FAE) of Peyer's patches (PPs) transports antigens and microorganisms into mucosal lymphoid tissues where they are captured by subepithelial dendritic cells (DCs). Feeding of cholera toxin (CT) induced migration of subepithelial DCs to interfollicular T-cell areas within 24 h. This study investigated short-term effects of CT, Escherichia coli heat-labile toxin, and non-toxic derivatives on DC migration. CT or CTB injected into ligated intestinal loops induced… CONTINUE READING

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