Cholera and Shiga toxin B-subunits: thermodynamic and structural considerations for function and biomedical applications.

@article{Pina2005CholeraAS,
  title={Cholera and Shiga toxin B-subunits: thermodynamic and structural considerations for function and biomedical applications.},
  author={David G. Pina and Ludger Johannes},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={45 4},
  pages={389-93}
}
The B-subunits of cholera and Shiga toxins are functionally and structurally related proteins with different chain lengths and no sequence similarity. They are responsible for toxin binding to specific glycosphingolipid receptors and intracellular toxin trafficking. Indeed, it is clearly established that B-subunits have the unique capacity of targeting the… CONTINUE READING