Cholera: calamitous past, ominous future.

@article{Lacey1995CholeraCP,
  title={Cholera: calamitous past, ominous future.},
  author={Stephen W. Lacey},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1995},
  volume={20 5},
  pages={
          1409-19
        }
}
  • S. W. Lacey
  • Published 1 May 1995
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
From the pandemics of the 19th century to the recent disaster in Goma, Zaire, cholera has left an indelible mark on human and medical history. Cholera pandemics in the 19th and 20th centuries drove the development of epidemiology as a serious science. Cholera has continued to press advances in the concepts of disease ecology, basic membrane biology, and transmembrane signaling and in the application of scientific information to treatment design. Furthermore, the lessons learned from the study… 
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References

SHOWING 1-10 OF 68 REFERENCES
Epidemiology of cholera.
TLDR
Proper and timely rehydration therapy can reduce mortality to less than 1%, and antibiotic treatment can decrease shedding of vibrios, but neither of these treatment measures has significantly altered the spread of disease.
Cholera in Louisiana: old problem, new light.
  • M. Levine
  • Medicine
    The New England journal of medicine
  • 1980
TLDR
It is the unqualified opinion of all the physicians with whom the physicians have consulted in the City of New Orleans, that the cholera of the spring of 1873 in that city and vicinity was native in its origin.
Treatment of cholera--tradition and authority versus science, reason, and humanity.
TLDR
Focus is on the erratic nature of the evolution of therapy in the field of cholera and the addition of the antimicrobial agents and oral electrolyte solutions means adequate therapy should be available to all patients with this disease.
Cholera nomenclature and nosology: a historical note.
The term "cholera" appears several times in the Hippocratic writings, and for more than 2 000 years designated ill-defined sporadic gastrointestinal derangements of diverse etiology. When the first
The Queensland cholera incident of 1977. 2. The epidemiological investigation.
TLDR
From the persistence of the microorganism in the first river over a two-month period, it seems that the cholera vibrio can not only survive for a long period but can also grow in the river water, which strongly suggests that certain surface, and possibly subsurface, waters may serve as potential silent foci of V. cholerae.
Notes on paracholera in Sulawesi (Celebes).
  • S. Tanamal
  • Medicine
    The American journal of tropical medicine and hygiene
  • 1959
Summary An epidemic of paracholera in Sulawesi, which occurred in 1947 and 1948, is described, in connection with three previous outbreaks in which this disease was diagnosed on the same island. No
Pathogenesis and ecology: the case of cholera.
TLDR
The way in which the results of various studies of cholera have influenced the understanding of the disease are discussed and the importance of the environmental reservoir of V. cholerae as the engine for the generation of diversity is highlighted.
The Broad Street pump revisited: response of volunteers to ingested cholera vibrios.
TLDR
Results of studies conducted in volunteers infected with varying doses of classic cholera strains are presented, establishing the postulates of Snow and Koch regarding the infectivity and virulence of Vibrio cholerae for man.
Cholera in Africa: lessons on transmission and control for Latin America
...
...