Cholecystokinin-stimulated insulin secretion and protein kinase C in rat pancreatic islets.

  title={Cholecystokinin-stimulated insulin secretion and protein kinase C in rat pancreatic islets.},
  author={Staffan Karlsson and Bo Ahr{\'e}n},
  journal={Acta physiologica Scandinavica},
  volume={142 3},
In isolated rat pancreatic islets, the possible involvement of protein kinase C in cholecystokinin-8-stimulated insulin secretion was investigated. In islets exposed for 24 hours to the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (500 nmol l-1), a procedure known to down-regulate islet protein kinase C-activity, the insulinotropic effect of cholecystokinin-8 (10(-7) mol l-1) was partially reduced (by 34 +/- 8%, P less than 0.001). In contrast the insulinotropic response to acute… CONTINUE READING


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