Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.

@article{Schmidt1994CholecystokininIA,
  title={Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.},
  author={Wolfgang Schmidt and Simon Schenk and Rainer Nustede and Jens Juul Holst and Ulrich Robert Foelsch and Werner O. C. Creutzfeldt},
  journal={Gastroenterology},
  year={1994},
  volume={107 6},
  pages={1610-20}
}
BACKGROUND/AIMS The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled study. METHODS Acid output was studied in eight subjects who received intravenously gastrin-17 (15, 30, and 60 pmol.kg-1.h-1); gastrin-17 plus lox; cholecystokinin octapeptide (CCK… CONTINUE READING