Cholecystokinin-induced phosphatidylinositol hydrolysis in rat pancreatic acinar cells: modulation by extracellular calcium and manganese.

@article{Korc1991CholecystokinininducedPH,
  title={Cholecystokinin-induced phosphatidylinositol hydrolysis in rat pancreatic acinar cells: modulation by extracellular calcium and manganese.},
  author={Murray Korc and Bysani Chandrasekar and Steven A. Siwik},
  journal={Endocrinology},
  year={1991},
  volume={129 1},
  pages={
          39-46
        }
}
The role of extracellular calcium in modulating the actions of cholecystokinin octapeptide (CCK8) on phosphatidylinositol 4,5-bisphosphate hydrolysis was studied in freshly isolated rat pancreatic acini and cultured AR42J cells. In both cell types, CCK8 rapidly induced the formation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and 1,3,4, 5-tetrakisphosphate [Ins(1,3,4,5)P4]. The actions of CCK8 were inhibited by lanthanum and manganese, agents that block transmembrane calcium fluxes, and by… 
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