Cholecystokinin from the entorhinal cortex enables neural plasticity in the auditory cortex

@inproceedings{Li2014CholecystokininFT,
  title={Cholecystokinin from the entorhinal cortex enables neural plasticity in the auditory cortex},
  author={Xiao Yan Li and Kai Yu and Zicong Zhang and Wenjian Sun and Zhuo Yang and Jingyu Feng and Xi E. Chen and Chun-Hua Liu and Haitao Wang and Yi Ping Guo and Jufang He},
  booktitle={Cell Research},
  year={2014}
}
Patients with damage to the medial temporal lobe show deficits in forming new declarative memories but can still recall older memories, suggesting that the medial temporal lobe is necessary for encoding memories in the neocortex. Here, we found that cortical projection neurons in the perirhinal and entorhinal cortices were mostly immunopositive for cholecystokinin (CCK). Local infusion of CCK in the auditory cortex of anesthetized rats induced plastic changes that enabled cortical neurons to… CONTINUE READING