Cholecystokinin elicits Satiety in Rats with Open Gastric Fistulas

@article{Gibbs1973CholecystokininES,
  title={Cholecystokinin elicits Satiety in Rats with Open Gastric Fistulas},
  author={James Gibbs and Robert H. Young and Gerard P. Smith},
  journal={Nature},
  year={1973},
  volume={245},
  pages={323-325}
}
WITHIN 10 min of starting to eat, a rat stops eating1, grooms for a short period, then usually sleeps. We define this behavioural sequence as satiety: its physiological basis is unknown. Beaumont2 presented the first evidence that the presence of food in the gut is important in generating satiety signals. In 1949, Janowitz and Grossman3 confirmed Pavlov's observation4 that oesophagostomized dogs, in which no food reached the stomach or intestines, ate prolonged meals. 

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