Cholecystokinin and anorexia in sheep infected by the intestinal nematode Trichostrongylus colubriformis.

@article{Symons1981CholecystokininAA,
  title={Cholecystokinin and anorexia in sheep infected by the intestinal nematode Trichostrongylus colubriformis.},
  author={L. E. A. Symons and D. R. Hennessy},
  journal={International journal for parasitology},
  year={1981},
  volume={11 1},
  pages={
          55-8
        }
}
  • L. Symons, D. Hennessy
  • Published 1 February 1981
  • Biology, Medicine
  • International journal for parasitology
Anorexia in rats infected with the nematode, Nippostrongylus brasiliensis: experimental manipulations
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Using the anthelminthic, mebendazole (MBZ), N. brasiliensis infections of the rat were eliminated between the first and second anorexic episodes, preventing the expression of the second phase of anorexia.
Anorexia Induced by the Parasitic Nematode, Nippostrongylus brasiliensis: Effects on NPY and CRF Gene Expression in the Rat Hypothalamus
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Surprisingly, it is found that increases in NPY gene expression in the hypothalamic arcuate nucleus (ARC) accompany anorexia in rats infected with N. brasiliensis, suggesting that animals detect a state of energy deficit during the early stages of the infection, yet do not feed, but become hyperphagic coincident with worm loss.
Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist
TLDR
The results indicate an involvement of central CCK receptors in regulation of feed intake depression following gastrointestinal parasitism of sheep and the possibility of a similar role in non-infected sheep and do not support the singular importance of a peripheral action of CCK in determining satiety.
The role of cholecystokinin in interleukin-1-induced anorexia
Suppression of food intake is linked to enteric inflammation in nematode-infected rats.
TLDR
The results suggest that suppressed host food intake during enteric T. spiralis infection is directly linked to intestinal inflammation.
Immune response and performance of growing Santa Ines lambs to artificial Trichostrongylus colubriformis infections
This study was carried out to evaluate the immune response and the impact of Trichostrongylus colubriformis infections on the performance of growing Santa Ines lambs. Thirty male lambs, 3–4 months of
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References

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Corrigendum - Skeletal muscle, liver and wool protein synthesis by sheep infected by the nematode Trichostrongylus colubriformis
TLDR
The results show that the same depression of skeletal muscle and, possibly, elevation of liver protein synthesis occur in a ruminant as were reported earlier for laboratory monogastric animals with intestinal nematode infections.
Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain
TLDR
Two octapeptides corresponding to the CCK-like component previously identified by RIA are purified from sheep brain, and the isolation, sequence and some properties of these molecules are reported.
Cholecystokinin-decreased food intake in rhesus monkeys.
TLDR
It is demonstrated that intravenous exogenous CCK suppresses feeding in rhesus monkeys and suggested that endogenous CCK has the same effect; they are consistent with the hypothesis that CCK is a satiety signal.
Efffect of vasoactive intestinal polypeptide on gallbladder smooth muscle in vitro.
TLDR
It is proposed that VIP can affect gallbladder motor activity by decreaseing smooth muscle tone and by antagonizing cholecystokinin, and lend further support to the proposal that gallbladders motor function may depend upon the action and interaction of the gastrointestinal hormones.
Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding.
TLDR
Findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake in sheep deprived of food.
Secretin cells in coeliac disease
TLDR
In 11 of the 16 coeliacs there was generalized hyperplasia of endocrine cells and, specifically, of the secretin (S) cells, and further studies may establish whether the S cells are abnormally storing hormone because of inability to release it or because of excess production.
Abnormalities of serum cholecystokinin and gallbladder emptying in celiac disease.
TLDR
A small amount of cholecystokinin-pancreozymin, a polypeptide hormone that acts as a ‘spatially aggregating force’ to regulate the activity of other hormones in the digestive system, is found to be beneficial in mice.
The Mucosa of the Small Intestine
TLDR
Observations that abnormalities of the intestinal mucosa might be present in patients suffering from intestinal malabsorption syndrome contradicted Thaysen's view that any changes found in the intestine mucosa in tropical sprue or idiopathic steatorrhcea were due only to postmortem autolysis.
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