Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats.

@article{Lubbers2010CholecystokininCholecystokinin1RP,
  title={Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats.},
  author={Tim Lubbers and Jacco J de Haan and Misha D P Luyer and Isabelle Verbaeys and M'hamed Hadfoune and Cornelis H. C. Dejong and Wim A. Buurman and Jan Willem W. M. Greve},
  journal={Annals of surgery},
  year={2010},
  volume={252 2},
  pages={376-82}
}
OBJECTIVE The current study investigates activation of the nutritional anti-inflammatory pathway by lipid-rich nutrition. BACKGROUND Enteral nutrition activates humoral and neural pathways to regulate food intake and sustain energy balance. Recently, we demonstrated that enteral nutrition and in particular lipid-rich nutrition modulates inflammation and prevents organ damage. METHODS Male rats were fasted or fed lipid-rich nutrition before hemorrhagic shock. Disruption of afferent vagal… CONTINUE READING

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