Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice.

@article{Amigo2011CholecystectomyIH,
  title={Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice.},
  author={L Pi{\~n}eiro Amigo and Constanze Husche and Silvana Zanlungo and Dieter L{\"u}tjohann and Marco Arrese and Juan Francisco Miquel and Attilio A Rigotti and Flavio Nervi},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2011},
  volume={31 1},
  pages={52-64}
}
BACKGROUND & AIMS Bile acid (BA) pool size remains unchanged after cholecystectomy (XGB) but it circulates faster, exposing the enterohepatic system to an increased flux of BA. Triglyceride (TG) and BA metabolisms are functionally inter-related. We investigated whether ablation of the gallbladder (GB) modifies hepatic TG metabolism. METHODS Male mice were subjected to XGB and fed a normal diet. In some experiments, mice received a 1% nicotinic acid diet to block lipolysis. Parameters of BA… CONTINUE READING
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