Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis.

Abstract

UNLABELLED Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis. Here we tested the hypothesis that cholangiocyte senescence is a pathophysiologically important phenotype in PSC. We assessed markers of cellular senescence and senescence-associated secretory phenotype (SASP) in livers of patients with PSC, primary… (More)
DOI: 10.1002/hep.26993

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