Cholangiocyte biology
@article{Tietz2002CholangiocyteB, title={Cholangiocyte biology}, author={Pamela S. Tietz and Nicholas F. LaRusso}, journal={Current Opinion in Gastroenterology}, year={2002}, volume={22}, pages={279–287} }
Purpose of review Cholangiocytes are increasingly recognized as biologically important epithelia because of the diverse array of cellular processes in which they participate. Collectively, these processes define normal function and, when disturbed, account for abnormalities that cause disease. Advances in animal models and sophisticated technology in imaging and gene silencing have led to substantial progress in defining the roles that cholangiocytes play in signaling, transport of water, ions…
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References
SHOWING 1-9 OF 9 REFERENCES
The cholangiopathies: disorders of biliary epithelia.
- Medicine, BiologyGastroenterology
- 2004
Recognition of cholangiocyte heterogeeity along the biliary tree is necessary to understand and devise effective therapies for liver diseases and, potentially, to devise ovel, effective therapies.
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease.
- Medicine, BiologyThe American journal of pathology
- 2004
Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis.
- Medicine, BiologyJournal of hepatology
- 2004
Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion
- BiologyInfection and Immunity
- 2004
It is demonstrated that the discharge of C. parvum sporozoite apical organelle contents occurs and that it is temperature, intracellular calcium, and cytoskeleton dependent and required for host cell invasion, confirming that apicals organelles play a central role in C.parvum entry into host cells.
A paper describing P2X receptors in cholangiocytes and their contribution to local regulation of biliary secretion and bile formation
This paper explores the mechanisms of apical organelle discharge by C. parvum sporozoites
This excellent review highlights a classification of cholangiopathies, along with the respective potential to evolve to chronic progressive liver disease and the current therapeutic approaches
A description of the first mouse strain, generated by a targeted mutation of Pkhd1
Glucose-driven, aquaporin-mediated localized water influx is involved in the membrane protrusion during C. parvum cellular invasion