Cholangiocyte biology

  title={Cholangiocyte biology},
  author={Pamela S. Tietz and Nicholas F. LaRusso},
  journal={Current Opinion in Gastroenterology},
Purpose of review Cholangiocytes are increasingly recognized as biologically important epithelia because of the diverse array of cellular processes in which they participate. Collectively, these processes define normal function and, when disturbed, account for abnormalities that cause disease. Advances in animal models and sophisticated technology in imaging and gene silencing have led to substantial progress in defining the roles that cholangiocytes play in signaling, transport of water, ions… 
2 Citations
Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment
The molecular mechanisms supporting liver regeneration and parenchymal reconstitution are reviewed to determine potential targets that would be amenable for therapeutic manipulation to enhance liver regeneration.
Engineering large-scale perfused tissues via synthetic 3D soft microfluidics
It is demonstrated by scRNAseq and immunohistochemistry that neural differentiation is significantly accelerated in perfused neural constructs, and this fully synthetic vascularization platform opens the door to the generation of human tissue models at unprecedented scale and complexity.


The cholangiopathies: disorders of biliary epithelia.
Recognition of cholangiocyte heterogeeity along the biliary tree is necessary to understand and devise effective therapies for liver diseases and, potentially, to devise ovel, effective therapies.
Apical Organelle Discharge by Cryptosporidium parvum Is Temperature, Cytoskeleton, and Intracellular Calcium Dependent and Required for Host Cell Invasion
It is demonstrated that the discharge of C. parvum sporozoite apical organelle contents occurs and that it is temperature, intracellular calcium, and cytoskeleton dependent and required for host cell invasion, confirming that apicals organelles play a central role in C.parvum entry into host cells.
A paper describing P2X receptors in cholangiocytes and their contribution to local regulation of biliary secretion and bile formation
    This paper explores the mechanisms of apical organelle discharge by C. parvum sporozoites
      This excellent review highlights a classification of cholangiopathies, along with the respective potential to evolve to chronic progressive liver disease and the current therapeutic approaches
        A description of the first mouse strain, generated by a targeted mutation of Pkhd1
          Glucose-driven, aquaporin-mediated localized water influx is involved in the membrane protrusion during C. parvum cellular invasion