Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.

@article{Raggi2017CholangiocarcinomaSS,
  title={Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.},
  author={Chiara Raggi and Margherita Correnti and Antonio Sica and Jesper B Andersen and Vincenzo Cardinale and Domenico Alvaro and Giovanna Chiorino and Elisa Forti and Shannon S. Glaser and Gianfranco D Alpini and Annarita Destro and Francesca Sozio and Luca Di Tommaso and Massimo G Roncalli and Jes{\'u}s Mar{\'i}a Banales and C{\'e}dric Coulouarn and Lu{\'i}s Bujanda and Guido Torzilli and Pietro Invernizzi},
  journal={Journal of hepatology},
  year={2017},
  volume={66 1},
  pages={
          102-115
        }
}
BACKGROUND & AIMS A therapeutically challenging subset of cells, termed cancer stem cells (CSCs) are responsible for cholangiocarcinoma (CCA) clinical severity. Presence of tumor-associated macrophages (TAMs) has prognostic significance in CCA and other malignancies. Thus, we hypothesized that CSCs may actively shape their tumor-supportive immune niche. METHODS CCA cells were cultured in 3D conditions to generate spheres. CCA sphere analysis of in vivo tumorigenic-engraftment in immune… CONTINUE READING
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1Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, via Manzoni 113, 20089 Rozzano (Milan), Italy. Email: chiara.raggi@humanitasresearch.it

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Cholangiocarcinoma Stem-like Cells Shapes Tumor-initiating Niche

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