Cholangiocarcinoma: Current concepts and insights

@article{Gores2003CholangiocarcinomaCC,
  title={Cholangiocarcinoma: Current concepts and insights},
  author={G. Gores},
  journal={Hepatology},
  year={2003},
  volume={37}
}
  • G. Gores
  • Published 2003
  • Medicine
  • Hepatology
Approaching focal liver lesions.
  • F. Pons, J. Llovet
  • Medicine
  • Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
  • 2004
TLDR
The etiopathogenic diagnosis of focal liver lesions is based on clinical findings, laboratory data, imaging techniques, and frequently histology, and a definite diagnosis is established using two essential tests: imaging techniques and a cytohistologic study. Expand
Papel do Transplante Hepático no Tratamento do Colangiocarcinoma
............................................................................................................................ 2 Lista de abreviaturasExpand
Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma
TLDR
Outcome following neoadjuvant chemoradiation and liver transplantation for perihilar CCA is excellent and risk of dropout is related to patient and tumor characteristics and this can be used to guide patient counseling before enrollment. Expand
VEGF and cholangiocarcinoma: Feeding the tumor
TLDR
The aim of this review is to define angiogenesis and the formation of new blood vessels and highlight recent studies involving VEGF and cholangiocarcinoma along with new insights into microRNA regulation of V EGF during tumor growth and development. Expand
Accumulation of neoplastic traits prior to spontaneous in vitro transformation of rat cholangiocytes determines susceptibility to activated ErbB-2/Neu.
TLDR
It is concluded that during progression to high passage, cultured BDEC undergo preneoplastic changes that enhance their susceptibility to transformation by ErbB-2/Neu, a receptor tyrosine kinase previously reported to be at elevated levels in cholangiocarcinomas. Expand
The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin
TLDR
Cytokeratin 7 and CK19 expression, present in hepatic progenitor cells and in cholangiocytes but not in normal hepatocytes, has been reported in some hepatocellular carcinomas, but the incidence and relevance of this expression in HCC in Caucasians is not known. Expand
Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3
TLDR
In tumor samples from patients with ICC, increased TAN and TAM levels were correlated with elevated p-STAT3 expression and all three of those factors were independent predictors of patient outcomes. Expand
COUP-TFII promotes metastasis and epithelial-to-mesenchymal transition through upregulating Snail in human intrahepatic cholangiocarcinoma.
TLDR
Findings indicate that COUP-TFII promotes epithelial-to-mesenchymal transition and metastasis in ICC and suggest that this protein is a potential target for adjuvant therapy for these patients. Expand
COUP-TFII promotes metastasis and epithelial-to-mesenchymal transition through upregulating Snail in human intrahepatic cholangiocarcinoma.
TLDR
Findings indicate that COUP-TFII promotes epithelial-to-mesenchymal transition and metastasis in ICC and suggest that this protein is a potential target for adjuvant therapy for these patients. Expand
High Prevalence of Human Polyomavirus 7 in Cholangiocarcinomas and Adjacent Peritumoral Hepatocytes: Preliminary Findings
TLDR
The results strongly indicate thatHPyV7, HPyV6, and MCPyV infect bile duct epithelium, hepatocytes, and CCA cells, which possibly suggest an indirect role of these viruses in the etiopathogenesis of CCA. Expand
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