Cholangiocarcinoma: Current concepts and insights

  title={Cholangiocarcinoma: Current concepts and insights},
  author={Gregory J. Gores},
  • G. Gores
  • Published 1 May 2003
  • Medicine
  • Hepatology

Approaching focal liver lesions.

  • F. PonsJ. Llovet
  • Medicine
    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
  • 2004
The etiopathogenic diagnosis of focal liver lesions is based on clinical findings, laboratory data, imaging techniques, and frequently histology, and a definite diagnosis is established using two essential tests: imaging techniques and a cytohistologic study.

Papel do Transplante Hepático no Tratamento do Colangiocarcinoma

............................................................................................................................ 2 Lista de abreviaturas

Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma

Outcome following neoadjuvant chemoradiation and liver transplantation for perihilar CCA is excellent and risk of dropout is related to patient and tumor characteristics and this can be used to guide patient counseling before enrollment.

VEGF and cholangiocarcinoma: Feeding the tumor

The aim of this review is to define angiogenesis and the formation of new blood vessels and highlight recent studies involving VEGF and cholangiocarcinoma along with new insights into microRNA regulation of V EGF during tumor growth and development.

The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin

Cytokeratin 7 and CK19 expression, present in hepatic progenitor cells and in cholangiocytes but not in normal hepatocytes, has been reported in some hepatocellular carcinomas, but the incidence and relevance of this expression in HCC in Caucasians is not known.

Effect of Betulinic acid Extraction from Guava (Psidium guajava Linn.) Leaves Against Human Cholangiocarcinoma Cells

BA can inhibit the HuCCA cell viability and induce apoptosis of neoplastic cells and may be used as a novel therapeutic agent for the treatment of cholangiocarcinoma in the future.

Clinical outcomes for hilar and extrahepatic cholangiocarcinoma with adjuvant, definitive, or liver transplant-based neoadjuvant chemoradiotherapy strategies: a single-center experience.

Outcomes for patients with extrahepatic CCA were superior for those who underwent nCRT/orthotopic liver transplant or postsurgical aCRT than for patients treated with dCRT, highlighting a need for better therapies when surgery is not possible.



Positron emission tomography with [18F]fluoro‐2‐deoxy‐D‐glucose for diagnosis and staging of bile duct cancer

PET is highly sensitive and specific for the detection and localization of CC and can be helpful for diagnosis of distant metastases but is not suitable for detection of regional lymph node metastases.

Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.

The hypothesis that selective iNOS inhibitors may have chemopreventive properties and that coadministration with a selective COX-2 inhibitor may have additional chemopleventive potential is supported.

E‐cadherin gene mutations in human intrahepatic cholangiocarcinoma

Human ICCs were investigated for E‐cadherin gene mutations within exons 7, 8, and 9 and the relationships were analysed between their mutations and the immunohistochemical expression and high ICC histological grade.

p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.

Cholangiocarcinoma occurs frequently in patients with primary sclerosing cholangitis (PSC). We evaluated the incidence and prognostic significance of p53 protein overexpression and K-ras gene

Detection of telomerase activity in biopsy specimens for diagnosis of biliary tract cancers.

The detection of telomerase activity in biopsy specimens and p53 overexpression in combination with routine histologic examination may improve the diagnosis of biliary tract cancers.

Genetic and epigenetic alterations of the INK4a–ARF pathway in cholangiocarcinoma

The findings indicate that the INK4a–ARF locus is frequently inactivated in cholangiocarcinoma of the liver and occurs independently of the status of p53 or pRb.

Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets.

Findings suggest that aberrant expression of ERBB-2 and COX-2 is a common feature of human and rat cholangiocarcinomas and that targeting of both proteins may prove useful as a therapeutic strategy for this lethal cancer.