Choice of strong analgesic in terminal cancer: Diamorphine or morphine?

@article{Twycross1977ChoiceOS,
  title={Choice of strong analgesic in terminal cancer: Diamorphine or morphine?},
  author={Robert Geoffrey Twycross},
  journal={Pain},
  year={1977},
  volume={3},
  pages={93-104}
}
A controlled trial of diamorphine (diacetylmorphine, heroin) and morphine is reported in which the two drugs were administered regularly by mouth in individually determined effective analgesic doses. Elixirs contained cocaine hydrochloride 10 mg/dose; other drugs were prescribed when indicated clinically. 699 patients entered the trial and, of these, 146 crossed from diamorphine to morphine, or vice versa, after about two weeks using an oral potency ratio of 1.5/1 determined in a pilot trial… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Safety and Effectiveness of Palliative Drug Treatment in the Last Days of Life-A Systematic Literature Review.

VIEW 11 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Physiological Response to Opioids

Methadone for Pain Management: Past, Present and Future

  • Srini Chary
  • Medicine
  • Indian journal of palliative care
  • 2018

Wieder ein „War on Drugs“

VIEW 3 EXCERPTS
CITES BACKGROUND

Editorial Advisory Board.