Choice of random rather than imprinted X inactivation in female embryonic stem cell-derived extra-embryonic cells.

@article{Murakami2011ChoiceOR,
  title={Choice of random rather than imprinted X inactivation in female embryonic stem cell-derived extra-embryonic cells.},
  author={Kazuhiro Murakami and Kimi Araki and Satoshi Ohtsuka and Teruhiko Wakayama and Hitoshi Niwa},
  journal={Development},
  year={2011},
  volume={138 2},
  pages={197-202}
}
In female mammals, one of two X chromosomes is epigenetically inactivated for gene dosage compensation, known as X inactivation (Xi). Inactivation occurs randomly in either the paternal or maternal X chromosome in all embryonic cell lineages, designated as random Xi. By contrast, in extra-embryonic cell lineages, which are segregated from somatic cell lineages in pre-implantation development, the paternal X chromosome is selectively inactivated, known as imprinted Xi. Although it is speculated… CONTINUE READING
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