Choice of progestogen for endometrial protection in combination with transdermal estradiol in menopausal women

@article{Mueck2018ChoiceOP,
  title={Choice of progestogen for endometrial protection in combination with transdermal estradiol in menopausal women},
  author={A. Mueck and T. Roemer},
  journal={Hormone Molecular Biology and Clinical Investigation},
  year={2018},
  volume={37}
}
  • A. Mueck, T. Roemer
  • Published 2018
  • Medicine, Biology
  • Hormone Molecular Biology and Clinical Investigation
  • Abstract Transdermal estradiol (TE) application (using gels, patches or a novel spray) is now a preferred route of hormone therapy (HT) in menopausal women, because various risks such as venous thromboembolism, stroke and unwanted hepatic effects can be reduced compared with oral HT. However, in the presence of an intact uterus, concurrent administration of progestogen is needed for endometrial protection. Due to the variety of progestogens available and differences in their clinical effects… CONTINUE READING
    5 Citations

    Figures, Tables, and Topics from this paper

    Norethisterone and its acetate - what's so special about them?
    • 1
    Will estradiol/progesterone capsules for oral use become the best choice for menopausal hormone therapy?
    • A. Mueck, X. Ruan
    • Medicine
    • Climacteric : the journal of the International Menopause Society
    • 2019
    Perimenopausal contraception
    Blutungsstörungen unter HRT
    • T. Roemer
    • Medicine
    • Journal für Gynäkologische Endokrinologie/Schweiz
    • 2020

    References

    SHOWING 1-10 OF 95 REFERENCES
    Endometrial response to concurrent treatment with vaginal progesterone and transdermal estradiol
    • 7
    • PDF
    Safety and comfort of long-term continuous combined transdermal estrogen and intrauterine levonorgestrel administration for postmenopausal hormone substitution – a review
    • D. Wildemeersch
    • Medicine
    • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
    • 2016
    • 7
    Vaginal micronized progesterone in continuous hormone replacement therapy. A prospective randomized study.
    • 6
    • Highly Influential
    Transdermal estradiol and oral or vaginal natural progesterone: bleeding patterns
    • 15
    • PDF
    The impact of micronized progesterone on the endometrium: a systematic review
    • 39
    • PDF
    The role of transdermal estrogen sprays and estradiol topical emulsion in the management of menopause-associated vasomotor symptoms
    • 10
    • PDF
    Bioidentical menopausal hormone therapy: registered hormones (non-oral estradiol ± progesterone) are optimal
    • M. L’hermite
    • Medicine
    • Climacteric : the journal of the International Menopause Society
    • 2017
    • 10
    Nomegestrol acetate, a novel progestogen for oral contraception
    • 70
    Transdermal sequential and continuous hormone replacement regimens with estradiol and norethisterone acetate in postmenopausal women: effects on the endometrium.
    • 18