Choice of calcineurin inhibitor may influence the development of de novo immune hepatitis associated with anti-GSTT1 antibodies after liver transplantation.

@article{Aguilera2011ChoiceOC,
  title={Choice of calcineurin inhibitor may influence the development of de novo immune hepatitis associated with anti-GSTT1 antibodies after liver transplantation.},
  author={Isabel Aguilera and Jos{\'e} Esteves Sousa and Juan M Praena and Miguel {\'A}ngel G{\'o}mez-Bravo and Antonio N{\'u}{\~n}ez-Rold{\'a}n},
  journal={Clinical transplantation},
  year={2011},
  volume={25 2},
  pages={207-12}
}
In 2004, we defined the genetic mismatch in the glutathione S-transferase T1 (GSTT1) gene positive donor/null recipient as a risk factor to develop de novo immune hepatitis (IH) after liver transplant (LT), which is always associated with production of donor-specific anti-GSTT1 antibodies. However, there are several unresolved questions, such as why some of these patients produce antibodies, why others do not and why not all of the patients with antibodies develop the disease. The aim of this… CONTINUE READING

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