Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.

@article{Gisbert2006ChoiceOA,
  title={Choice of azathioprine or 6-mercaptopurine dose based on thiopurine methyltransferase (TPMT) activity to avoid myelosuppression. A prospective study.},
  author={Javier P Gisbert and Marta Luna and Jos{\'e} Mat{\'e} and Luis Gonz{\'a}lez-Guijarro and Carlos J Cara and Jos{\'e} Mar{\'i}a Pajares},
  journal={Hepato-gastroenterology},
  year={2006},
  volume={53 69},
  pages={399-404}
}
BACKGROUND/AIMS To prospectively evaluate whether, in patients with inflammatory bowel disease, the choice of azathioprine (AZA) or 6-mercaptopurine (6-MP) dose based on thiopurine methyltransferase (TPMT) activity prevents myelotoxicity. METHODOLOGY TPMT activity in red blood cells was measured in 99 patients with Crohn's disease and 32 with ulcerative colitis prior to initiating AZA/6-MP treatment. AZA/6-MP dose was chosen based on TPMT activity, which was again determined one month after… CONTINUE READING