Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells.

@article{Schramm2001ChocolatePD,
  title={Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells.},
  author={Derek D. Schramm and Janice F. Wang and Roberta R. Holt and Jodi L. Ensunsa and Joanna Gonsalves and Sheryl A Lazarus and Harold H. Schmitz and J. Bruce German and Carl L. Keen},
  journal={The American journal of clinical nutrition},
  year={2001},
  volume={73 1},
  pages={36-40}
}
BACKGROUND Polyphenolic phytochemicals inhibit vascular and inflammatory processes that contribute to disease. These effects are hypothesized to result from polyphenol-mediated alterations in cellular eicosanoid synthesis. OBJECTIVE The objective was to determine and compare the ability of cocoa procyanidins to alter eicosanoid synthesis in human subjects and cultured human aortic endothelial cells. DESIGN After an overnight fast, 10 healthy subjects (4 men and 6 women) consumed 37 g low… CONTINUE READING