Chocolate matrix factors modulate the pharmacokinetic behavior of cocoa flavan-3-ol phase II metabolites following oral consumption by Sprague-Dawley rats.

@article{Neilson2010ChocolateMF,
  title={Chocolate matrix factors modulate the pharmacokinetic behavior of cocoa flavan-3-ol phase II metabolites following oral consumption by Sprague-Dawley rats.},
  author={Andrew P Neilson and Teryn N Sapper and Elsa M. Janle and Ralf Rudolph and Nathan V Matusheski and Mario G Ferruzzi},
  journal={Journal of agricultural and food chemistry},
  year={2010},
  volume={58 11},
  pages={6685-91}
}
The impact of carbohydrates and milk on the bioavailability of catechin (C) and epicatechin (EC) from chocolate has been previously studied. However, little data exist regarding potential modulation of the phase II metabolism by these chocolate matrix factors. The objectives of this study were to assess the impact of matrix composition on qualitative and quantitative profiles of circulating catechins and their metabolites following administration of commercially relevant chocolate confections… CONTINUE READING
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