Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior

@article{Sokolov2013ChocolateAT,
  title={Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior},
  author={Alexander N. Sokolov and Marina A Pavlova and Sibylle Klosterhalfen and Paul Enck},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2013},
  volume={37},
  pages={2445-2453}
}

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References

SHOWING 1-10 OF 111 REFERENCES
The neuroprotective effects of cocoa flavanol and its influence on cognitive performance.
  • A. Nehlig
  • Biology
    British journal of clinical pharmacology
  • 2013
TLDR
The present review intends to review the data available on the effects of cocoa and chocolate on brain health and cognitive abilities.
The Effect of Flavanol-rich Cocoa on the fMRI Response to a Cognitive Task in Healthy Young People
TLDR
The data presented show an increase in the BOLD signal intensity in response to a cognitive task following ingestion of flavanol-rich cocoa, suggesting the potential of cocoa flavanols for treatment of vascular impairment, including dementia and strokes, and thus for maintaining cardiovascular health.
Cocoa Flavanols and Brain Perfusion
TLDR
Preliminary data hold out the promise that the cerebral blood supply in the elderly participates in the vasodilator response, and the prospect of increasing cerebral perfusion with cocoa flavanols is extremely promising.
Cocoa and chocolate in human health and disease.
TLDR
Overall, research to date suggests that the benefits of moderate cocoa or dark chocolate consumption likely outweigh the risks, including increased risk of weight gain.
The neuroprotective potential of flavonoids: a multiplicity of effects
TLDR
The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs.
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
TLDR
Data show that ingestion of a single flavanol improves spatial memory retention in adult mammals, and is associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus.
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
  • H. Schroeter, C. Heiss, M. Kelm
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
TLDR
The data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa.
Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats
TLDR
Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases, and further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man.
...
...