• Corpus ID: 8781437

Chocolate : Modern Science Investigates an Ancient Medicine Effects of Cocoa Extracts on Endothelium-Dependent Relaxation 1

  title={Chocolate : Modern Science Investigates an Ancient Medicine Effects of Cocoa Extracts on Endothelium-Dependent Relaxation 1},
  author={Malina Karim and Kellie Mccormick and C. Tissa Kappagoda},
The aim of this study was to examine the effects of procyanidins derived from cocoa on vascular smooth muscle. Two hypotheses were tested: 1) extracts of cocoa, which are rich in procyanidins, cause endothelium-dependent relaxation (EDR), and 2) extracts of cocoa activate endothelial nitric oxide synthase (NOS). The experiments were carried out on aortic rings obtained from New Zealand White rabbits. The polymeric procyanidins (tetramer through decamer of catechin) caused an EDR. In addition… 

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