Chocolate : Modern Science Investigates an Ancient Medicine Effects of Cocoa Extracts on Endothelium-Dependent Relaxation 1
@inproceedings{Karim2000ChocolateM, title={Chocolate : Modern Science Investigates an Ancient Medicine Effects of Cocoa Extracts on Endothelium-Dependent Relaxation 1}, author={M. Karim and K. Mccormick and C. Kappagoda}, year={2000} }
The aim of this study was to examine the effects of procyanidins derived from cocoa on vascular smooth muscle. Two hypotheses were tested: 1) extracts of cocoa, which are rich in procyanidins, cause endothelium-dependent relaxation (EDR), and 2) extracts of cocoa activate endothelial nitric oxide synthase (NOS). The experiments were carried out on aortic rings obtained from New Zealand White rabbits. The polymeric procyanidins (tetramer through decamer of catechin) caused an EDR. In addition… CONTINUE READING
14 Citations
Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults
- Chemistry, Medicine
- Journal of the American College of Nutrition
- 2004
- 429
- PDF
Dark chocolate: consumption for pleasure or therapy?
- Medicine
- Journal of Thrombosis and Thrombolysis
- 2008
- 28
- PDF
Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells.
- Biology, Medicine
- Journal of agricultural and food chemistry
- 2011
- 64
Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases
- Medicine, Biology
- Oxidative medicine and cellular longevity
- 2016
- 42
- PDF
The effects of cocoa supplementation, caloric restriction, and regular exercise, on oxidative stress markers of brain and memory in the rat model.
- Chemistry, Medicine
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2013
- 14
- PDF
Effects of dark chocolate on blood pressure in patients with hypertension.
- Medicine
- American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
- 2012
- 6
A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats.
- Chemistry, Medicine
- Nutrition
- 2007
- 126
- PDF
References
SHOWING 1-10 OF 17 REFERENCES
Endothelium-dependent vasorelaxing activity of wine and other grape products.
- Biology, Medicine
- The American journal of physiology
- 1993
- 443
Effect of red wine on endothelium-dependent relaxation in rabbits.
- Chemistry, Medicine
- Clinical science
- 1997
- 91
- PDF
Phytoestrogens and inhibition of angiogenesis.
- Biology, Medicine
- Bailliere's clinical endocrinology and metabolism
- 1998
- 124
- PDF
HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity.
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 1999
- 380
- PDF
Evidence that expression of inducible nitric oxide synthase in response to endotoxin is augmented in atherosclerotic rabbits.
- Biology, Medicine
- Circulation research
- 1995
- 44
Effect of nisoldipine on atherosclerosis in the cholesterol fed rabbit: endothelium dependent relaxation and aortic cholesterol content.
- Medicine
- Cardiovascular research
- 1991
- 16
Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers.
- Medicine
- European journal of clinical nutrition
- 1996
- 126
High performance liquid chromatography / mass spectrometry analysis of proanthocyanidins in food stuffs
- J . Agric . Food Chem .
- 1999