Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.

Abstract

The integrity of the nuclear envelope barrier relies on membrane remodeling by the ESCRTs, which seal nuclear envelope holes and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes are mechanistically related remains poorly defined. Here, we show that the ESCRT-II/III chimera, Chm7, is recruited to a nuclear envelope… (More)

Topics

  • Presentations referencing similar topics