Chlorthalidone: has it always been the best thiazide-type diuretic?

  title={Chlorthalidone: has it always been the best thiazide-type diuretic?},
  author={Domenic A. Sica},
  volume={47 3},
Modern diuretic therapy evolved from 2 seemingly unrelated events in the 1930s: the development of sulfanilamide, the first truly effective antibacterial agent, and the description of the enzyme carbonic anhydrase. Sulfanilamide was observed to increase sodium (Na )/potassium and water excretion by inhibition of carbonic anhydrase activity. Recognition of this action proved the impetus for synthesis of compounds, such as acetazolamide, that could more specifically inhibit carbonic anhydrase… CONTINUE READING