Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.

@article{Caughlan2004ChlorpyrifosIA,
  title={Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.},
  author={Anne Caughlan and Kathleen Newhouse and Uk Namgung and Zhengui Xia},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={78 1},
  pages={125-34}
}
Chlorpyrifos, an acetylcholinesterase (AChE) inhibitor, is a widely used organophosphate pesticide. Recent concern has focused on its neurotoxicity that is not attributable to AChE inhibition. Here, we report that chlorpyrifos and chlorpyrifos-oxon, but not 3,5,6-trichloro-2-pyridinol (TCP; the breakdown product of chlorpyrifos and chlorpyrifos-oxon… CONTINUE READING