Chlorpyrifos‐induced DNA damage in rat liver and brain

@article{Mehta2008ChlorpyrifosinducedDD,
  title={Chlorpyrifos‐induced DNA damage in rat liver and brain},
  author={A. Mehta and R. S. Verma and N. Srivastava},
  journal={Environmental and Molecular Mutagenesis},
  year={2008},
  volume={49}
}
Chlorpyrifos (O,O'‐diethyl‐O‐3,5,6‐trichloro‐2‐pyridyl phosphorothionate, CPF) is a broad spectrum organophosphate pesticide used to control a variety of pests. The present study was undertaken to test the in vivo genotoxic potential of CPF in rats, using the single cell gel electrophoresis (or comet) assay. The rats were administered 50 mg and 100 mg CPF/kg body weight daily for 1, 2, and 3 days as well as 1.12 mg and 2.24 mg CPF/kg body weight for 90 days. The level of DNA damage was… Expand
Cytogenetic and Genotoxic Effects of Penconazole and Chlorpyrifos Pesticides in Bone Marrow of Rats
In vitro studies on organophosphate pesticides induced oxidative DNA damage in rat lymphocytes.
  • A. Ojha, N. Srivastava
  • Chemistry, Medicine
  • Mutation research. Genetic toxicology and environmental mutagenesis
  • 2014
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