Chlorpyrifos‐induced DNA damage in rat liver and brain

@article{Mehta2008ChlorpyrifosinducedDD,
  title={Chlorpyrifos‐induced DNA damage in rat liver and brain},
  author={A. Mehta and R. S. Verma and N. Srivastava},
  journal={Environmental and Molecular Mutagenesis},
  year={2008},
  volume={49}
}
Chlorpyrifos (O,O'‐diethyl‐O‐3,5,6‐trichloro‐2‐pyridyl phosphorothionate, CPF) is a broad spectrum organophosphate pesticide used to control a variety of pests. The present study was undertaken to test the in vivo genotoxic potential of CPF in rats, using the single cell gel electrophoresis (or comet) assay. The rats were administered 50 mg and 100 mg CPF/kg body weight daily for 1, 2, and 3 days as well as 1.12 mg and 2.24 mg CPF/kg body weight for 90 days. The level of DNA damage was… Expand
View on Wiley
ncbi.nlm.nih.gov
64 Citations
Highly Influential Citations
6
Background Citations
22
Methods Citations
1
Results Citations
3

64 Citations

Citation Type

Citation Type

Monocrotophos induced lipid peroxidation and oxidative DNA damage in rat tissues
Evaluation of genotoxic potential of commonly used organophosphate pesticides in peripheral blood lymphocytes of rats
Evaluation of DNA damage and cytotoxicity induced by three commonly used organophosphate pesticides individually and in mixture, in rat tissues
Evaluation of genotoxicity of monocrotophos and quinalphos in rats and protective effects of melatonin
Cytogenetic evaluation of malathion-induced toxicity in Sprague-Dawley rats.
Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver
Cytogenetic and Genotoxic Effects of Penconazole and Chlorpyrifos Pesticides in Bone Marrow of Rats
In vitro studies on organophosphate pesticides induced oxidative DNA damage in rat lymphocytes.
  • A. Ojha, N. Srivastava
  • Chemistry, Medicine
  • Mutation research. Genetic toxicology and environmental mutagenesis
  • 2014
The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis.
Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes.
Effect of chlorpyrifos on thiobarbituric acid reactive substances, scavenging enzymes and glutathione in rat tissues.
Evaluation of the genetic toxicity of the organophosphate insecticide chlorpyrifos.
DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism.
Comparative studies on lipid peroxidation and DNA-single strand breaks induced by lindane, DDT, chlordane and endrin in rats.
Lack of carcinogenicity of chlorpyrifos insecticide in a high-dose, 2-year dietary toxicity study in Fischer 344 rats.
Adriamycin-induced hepatic and myocardial lipid peroxidation and DNA damage, and enhanced excretion of urinary lipid metabolites in rats.
Genotoxic effects of malathion: an organophosphorus insecticide, using three mammalian bioassays in vivo.
Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes.
Evaluation of the genotoxic and embryotoxic potential of chlorpyrifos and its metabolites in vivo and in vitro.
...
1
2
3
4
5
...