Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumor-promoting phorbol esters and their specific receptors.

@article{Shoyab1982ChlorpromazineAR,
  title={Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumor-promoting phorbol esters and their specific receptors.},
  author={Mohammed Shoyab and George J. Todaro and John F. Tallman},
  journal={Cancer letters},
  year={1982},
  volume={16 2},
  pages={171-7}
}
Various antipsychotic and antidepressant drugs have been tested for their effects on the binding of [3H] phorbol-dibutyrate (PDBu) to its specific receptor. Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumor-promoting phorbol esters and their specific receptors. The relative potency of drugs in… CONTINUE READING