Chlorpromazine alters cochlear mechanics and amplification: in vivo evidence for a role of stiffness modulation in the organ of corti.

@article{Zheng2007ChlorpromazineAC,
  title={Chlorpromazine alters cochlear mechanics and amplification: in vivo evidence for a role of stiffness modulation in the organ of corti.},
  author={Jiefu Zheng and Niranjan Deo and Yuan Zou and Karl Grosh and Alfred L. Nuttall},
  journal={Journal of neurophysiology},
  year={2007},
  volume={97 2},
  pages={
          994-1004
        }
}
Although prestin-mediated outer hair cell (OHC) electromotility provides mechanical force for sound amplification in the mammalian cochlea, proper OHC stiffness is required to maintain normal electromotility and to transmit mechanical force to the basilar membrane (BM). To investigate the in vivo role of OHC stiffness in cochlear amplification, chlorpromazine (CPZ), an antipsychotic drug that alters OHC lateral wall biophysics, was infused into the cochleae in living guinea pigs. The effects of… CONTINUE READING

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