Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial

@article{Sulo2002ChlorproguanildapsoneVS,
  title={Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial},
  author={J Sulo and Phillips Chimpeni and Juanita Hatcher and JG Kublin and PA Winstanley},
  journal={The Lancet},
  year={2002},
  volume={360},
  pages={1136-1143}
}
BACKGROUND Chlorproguanil-dapsone exerts lower resistance pressure on Plasmodium falciparum than does sulfadoxine-pyrimethamine, but is rapidly eliminated. We aimed to find out whether chlorproguanil-dapsone results in a higher retreatment rate for malaria than sulfadoxine-pyrimethamine. METHODS In a randomised trial of paediatric outpatients with uncomplicated falciparum malaria, patients received either chlorproguanil-dapsone or sulfadoxine-pyrimethamine and were followed up for up to 1… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients

  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Malaria research and its influence on anti-malarial drug policy in Malawi: a case study

  • Health Research Policy and Systems
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED