Chlorpheniramine plasma concentration and histamine H1‐receptor occupancy

  title={Chlorpheniramine plasma concentration and histamine H1‐receptor occupancy},
  author={S. Yasuda and A. Wellstein and P. Likhari and J. Barbey and R. Woosley},
  journal={Clinical Pharmacology & Therapeutics},
  • S. Yasuda, A. Wellstein, +2 authors R. Woosley
  • Published 1995
  • Chemistry, Medicine
  • Clinical Pharmacology & Therapeutics
  • The plasma concentration‐response relationship of the antihistamine chlorpheniramine is poorly characterized. This study examined concurrently the concentrations of chlorpheniramine and presence of H1‐receptor antagonist in plasma after administration of 8 mg chlorpheniramine in normal volunteers. Six extensive metabolizers and five poor metabolizers, as judged by CYP2D6 phenotype (dextromethorphan metabolic ratio), were enrolled in the study. More than 80% occupancy of H1‐receptors by… CONTINUE READING
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